EWAS of lung function in Latinos with asthma - Summary Statistics

  1. Herrera-Luis, Esther 1
  2. Li, Annie 2
  3. Mak, Angel C. Y. 2
  4. Perez-Garcia, Javier 1
  5. Elhawary, Jennifer R. 2
  6. Oh, Sam S. 2
  7. Hu, Donglei 2
  8. Eng, Celeste 2
  9. Keys, Kevin L. 3
  10. Huntsman, Scott 2
  11. Beckman, Kenneth B. 4
  12. Borrell, Luisa N. 5
  13. Rodriguez-Santana, Jose 6
  14. Burchard, Esteban G. 7
  15. Pino-Yanes, Maria 8
  1. 1 Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Tenerife, Spain
  2. 2 Department of Medicine, University of California San Francisco, San Francisco, California, USA
  3. 3 Department of Medicine, University of California San Francisco, San Francisco, California, USA & Berkeley Institute for Data Science, University of California Berkeley, Berkeley, CA, USA
  4. 4 UMN Genomics Center, Minneapolis, MN, USA
  5. 5 Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, NY, United States of America
  6. 6 Centro de Neumología Pediátrica, San Juan, Puerto Rico.
  7. 7 Department of Medicine, University of California San Francisco, San Francisco, California, USA & Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA
  8. 8 Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain & Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, San Cristóbal de La Laguna, Tenerife, Spain
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Editor: Zenodo

Año de publicación: 2021

Tipo: Dataset

DOI: 10.5281/ZENODO.5236668 lock_openAcceso abierto editor

Resumen

Summary statistics generated for the manuscript entitled <strong>"Epigenome-wide association study of lung function in Latino children and youth with asthma"</strong> Our aim was to identify DNA methylation signals associated with lung function in Latino youth with asthma and validate previous epigenetic signals from non-Latino populations. For that, we performed multiple epigenome-wide association studies (EWAS) of lung function measurements analyzing whole blood from 250 Puerto Rican (PR) and 148 Mexican American (MEX) youth with asthma from the Genes-Environment and Admixture in Latino Americans (GALA II) study. The following measurements were evaluated Pre- and post- albuterol administration: Forced expiratory volume in one second (FEV1.Meas), forced vital capacity (FVC.Meas) and their ratio (FEV1.FVC.Meas). DNA methylation was profiled with the Infinium EPIC BeadChip or the Infinium HumanMethylation450 BeadChip array (Illumina, San Diego, CA, USA). The association of methylation beta-values and raw PFT values (in liters) was tested by robust linear regressions with correction for age, sex, height, the first three genotype principal components (PCs),<em> in utero</em> maternal smoking exposure, the first six ReFACTor components, and batch, when appropriate, via limma R package. The results for individuals of the same ethnic subgroup were meta-analyzed using fixed- or random-effects models, based on Cochran's Q p-value. Version 1 is deprecated. The EWAS result files (*.txt) contains: RSID: CpG name. STUDY: Number of sets of individuals included in the meta-analysis. BETA_meta: Coefficient of the regression. SEBETA_meta: Standard error of the coefficient of the regression. PVALUE_meta: P-value for the association. PVALUE_Q: Cochran's Q p-value. Model: Fixed-effect (FE) or Random-effects (RE2) model. PVALUE_meta_adj: False discovery rate (Benjamini &amp; Hochberg method).