Química y Bioactividad de Compuestos basados en Productos Naturales
QUIBIONAT
Universidad de Las Palmas de Gran Canaria
Las Palmas de Gran Canaria, EspañaPublicaciones en colaboración con investigadores/as de Universidad de Las Palmas de Gran Canaria (22)
2022
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Discovery of Highly Functionalized 5-hydroxy-2H-pyrrol-2-ones That Exhibit Antiestrogenic Effects in Breast and Endometrial Cancer Cells and Potentiate the Antitumoral Effect of Tamoxifen
Cancers, Vol. 14, Núm. 21
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Guanidine Derivatives Containing the Chalcone Skeleton Are Potent Antiproliferative Compounds against Human Leukemia Cells
International journal of molecular sciences, Vol. 23, Núm. 24
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Structure-activity relationships reveal a 2-furoyloxychalcone as a potent cytotoxic and apoptosis inducer for human U-937 and HL-60 leukaemia cells
Bioorganic Chemistry, Vol. 127
2021
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JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia
Biomedicine and Pharmacotherapy, Vol. 144
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Modular synthesis and antiproliferative activity of new dihydro-1H-pyrazolo[1,3-b]pyridine embelin derivatives
Pharmaceuticals, Vol. 14, Núm. 10
2020
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Efficient Multicomponent Synthesis of Diverse Antibacterial Embelin-Privileged Structure Conjugates
Molecules (Basel, Switzerland), Vol. 25, Núm. 14
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The synthetic flavanone 6-methoxy-2-(naphthalen-1-yl)chroman-4-one induces apoptosis and activation of the MAPK pathway in human U-937 leukaemia cells
Bioorganic Chemistry, Vol. 94
2019
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A novel naphthoquinone-coumarin hybrid that inhibits BCR-ABL1-STAT5 oncogenic pathway and reduces survival in imatinib-resistant chronic myelogenous leukemia cells
Frontiers in Pharmacology, Vol. 9, Núm. JAN
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Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology
Oncogene, Vol. 38, Núm. 24, pp. 4657-4668
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Synthesis and antiplasmodial activity of 1,2,3-triazole-naphthoquinone conjugates
Molecules, Vol. 24, Núm. 21
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Synthesis, characterization and antiproliferative activity of mixed ligand complexes of Cu2+ and Co2+ with lapachol
Polyhedron, Vol. 165, pp. 73-78
2018
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3′-Hydroxy-3,4′-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK
Chemico-Biological Interactions, Vol. 288, pp. 1-11
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Correction: CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia [Oncotarget, 8 (2017) (29679-29698)] Doi: 10.18632/oncotarget.11425
Oncotarget
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Lawsone, Juglone, and β-Lapachone Derivatives with Enhanced Mitochondrial-Based Toxicity
ACS Chemical Biology, Vol. 13, Núm. 8, pp. 1950-1957
2017
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3′-Hydroxy-3,4′-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells
Bioorganic and Medicinal Chemistry, Vol. 25, Núm. 21, pp. 6060-6070
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5-Ethynylarylnaphthalimides as antitumor agents: Synthesis and biological evaluation
Bioorganic and Medicinal Chemistry, Vol. 25, Núm. 6, pp. 1976-1983
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CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia
Oncotarget, Vol. 8, Núm. 18, pp. 29679-29698
2016
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Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species
Chemico-Biological Interactions, Vol. 256, pp. 220-227
2015
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Synthesis of 4,4′-Diaminotriphenylmethanes with Potential Selective Estrogen Receptor Modulator (SERM)-like Activity
ChemMedChem, Vol. 10, Núm. 8, pp. 1403-1412
2014
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Indium catalyzed solvent-free multicomponent synthesis of cytotoxic dibenzo[a,h]anthracenes from aldehydes, 2-hydroxy-1,4-naphthoquinone, and 2-naphthol
Tetrahedron, Vol. 70, Núm. 45, pp. 8480-8487