Eduardo Carlos
Salido Ruiz
Catedrático de Universidad
Universidad de Granada
Granada, EspañaPublicaciones en colaboración con investigadores/as de Universidad de Granada (31)
2024
-
Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants
FEBS Letters, Vol. 598, Núm. 4, pp. 485-499
2023
-
Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme*
FEBS Journal, Vol. 290, Núm. 7, pp. 1855-1873
2022
-
Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity‐Making Mutations
Antioxidants, Vol. 11, Núm. 6
-
Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations
Archives of Biochemistry and Biophysics, Vol. 729
-
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
Frontiers in Molecular Biosciences, Vol. 9
-
Lactate dehydrogenase A inhibitors with a 2,8-dioxabicyclo[3.3.1]nonane scaffold: A contribution to molecular therapies for primary hyperoxalurias
Bioorganic Chemistry, Vol. 129
-
New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production
European Journal of Medicinal Chemistry, Vol. 237
-
Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants
Molecules (Basel, Switzerland), Vol. 27, Núm. 24
-
Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
Journal of Personalized Medicine, Vol. 12, Núm. 5
2021
-
Small molecule-based enzyme inhibitors in the treatment of primary hyperoxalurias
Journal of Personalized Medicine, Vol. 11, Núm. 2, pp. 1-31
-
Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue
Redox Biology, Vol. 46
2020
-
Naturally-occurring rare mutations cause mild to catastrophic effects in the multifunctional and cancer-associated NQO1 protein
Journal of Personalized Medicine, Vol. 10, Núm. 4, pp. 1-31
2019
-
A dynamic core in human NQO1 controls the functional and stability effects of ligand binding and their communication across the enzyme dimer
Biomolecules, Vol. 9, Núm. 11
-
Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses
Human Molecular Genetics, Vol. 28, Núm. 1, pp. 1-15
-
Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I
Advances in Protein Chemistry and Structural Biology (Academic Press Inc.), pp. 119-152
-
Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1
Nucleic Acid Therapeutics, Vol. 29, Núm. 2, pp. 104-113
2018
-
Evolutionary divergent suppressor mutations in conformational diseases
Genes, Vol. 9, Núm. 7
-
Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer
Handbook of Experimental Pharmacology (Springer New York LLC), pp. 155-190
-
Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1
Journal of Medicinal Chemistry, Vol. 61, Núm. 16, pp. 7144-7167
2017
-
Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution
Human Molecular Genetics, Vol. 26, Núm. 18, pp. 3531-3544