Química Orgánica
Departamento
Miguel Xavier
Fernandes
Investigador en el periodo 2013-2022
Publicaciones en las que colabora con Miguel Xavier Fernandes (16)
2024
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Coumarin-azasugar-benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth
Organic & biomolecular chemistry, Vol. 22, Núm. 17, pp. 3425-3438
2023
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Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
International Journal of Molecular Sciences, Vol. 24, Núm. 11
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Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 38, Núm. 1, pp. 349-360
2022
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2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 37, Núm. 1, pp. 168-177
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A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors
Frontiers in Pharmacology, Vol. 13
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A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)
Journal of enzyme inhibition and medicinal chemistry, Vol. 37, Núm. 1, pp. 2395-2402
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Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
Bioorganic Chemistry, Vol. 127
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Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations
International Journal of Molecular Sciences, Vol. 23, Núm. 14
2021
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Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 36, Núm. 1, pp. 138-146
2020
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CKT0353, a novel microtubule targeting agent, overcomes paclitaxel induced resistance in cancer cells
Investigational New Drugs, Vol. 38, Núm. 3, pp. 584-598
2019
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Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations
European Journal of Medicinal Chemistry, Vol. 179, pp. 493-501
2018
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Anti-Proliferative 1,4-Dihydropyridine and Pyridine Derivatives Synthesized through a Catalyst-Free, One-Pot Multi-Component Reaction
ChemistrySelect, Vol. 3, Núm. 43, pp. 12163-12168
2017
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DTA0100, dual topoisomerase II and microtubule inhibitor, evades paclitaxel resistance in P-glycoprotein overexpressing cancer cells
European Journal of Pharmaceutical Sciences, Vol. 105, pp. 159-168
2015
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Synthesis and identification of unprecedented selective inhibitors of CK1ε
European Journal of Medicinal Chemistry, Vol. 96, pp. 308-317
2013
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Generation of artificial neural networks models in anticancer study
Neural Computing and Applications, Vol. 23, Núm. 3-4, pp. 577-582
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Molecular docking studies of the interaction between propargylic enol ethers and human DNA topoisomerase IIα
Bioorganic and Medicinal Chemistry Letters, Vol. 23, Núm. 19, pp. 5382-5384