Efectos de la castración perinatal y prepuberal sobre la amígdala cerebral

  1. Emilia María Carmona Calero 1
  2. Juan M. González Toledo 1
  3. Paula Soberón Rodríguez 1
  4. Rosa J. Tejera Pérez 1
  5. Bárbara Agostina Valenzuela 1
  6. Leandro Castañeyra Ruiz 1
  7. Luis García Hernández Abad 2
  8. Ibrahim González Marrero 1
  9. Agustín Lorenzo Castañeyra Perdomo 1
  1. 1 Universidad de La Laguna

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    ROR https://ror.org/01r9z8p25

  2. 2 Instituto de Investigación y Ciencias, Puerto del Rosario, Fuerteventura
Majorensis: Revista Electrónica de Ciencia y Tecnología

ISSN: 1697-5529

Year of publication: 2017

Issue: 13

Pages: 11-20

Type: Article

More publications in: Majorensis: Revista Electrónica de Ciencia y Tecnología


The amygdala is considered as the center of the emotions and regulator of reactions of aggressiveness, fear and anxiety. In humans the amygdala is associated with emotional learning and social behavior. The amygdala also plays an important role in sexual behavior. In our study, we used as experimental animal male mice divided into: a control group and two experimental groups formed by newborn castrated mice and pre-puberty castrated mice. They were sacrificed at 5, 35 and 85 days of age. The histological techniques used were Klüver-Barrera and immunohistochemistry with anti-NeuN. Pre-puberty castration affected very little the parts of the amygdala complex. In contrast, neonatal castration produced changes in the neurons of the medial nucleus of the amygdala showed different density and neuronal nuclear area as they are: the number of neurons presents a marked decrease in castrated mice Neonates and a decrease in the size of most nuclei of medial amygdala neurons at 35 and 85 days of age. We can conclude that pre-puberty castration (20 days) affects very little the global and neural morphology of the different parts of the tonsillar complex. In contrast, castration in neonates induces variations in the medial tonsillar nuclei that are most related to the sexual maturation of the brain described in the mouse in the first postnatal days