Cognitive Impairment in Parkinson's DiseaseMore than a Frontostriatal Dysfunction

  1. Galtier Hernández, Iván
  2. Nieto Barco, María Antonieta
  3. Lorenzo, Jesús Norelis
  4. Barroso Ribal, José
Revue:
The Spanish Journal of Psychology

ISSN: 1138-7416

Année de publication: 2014

Volumen: 17

Pages: 1-8

Type: Article

DOI: 10.1017/SJP.2014.69 DIALNET GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: The Spanish Journal of Psychology

Résumé

Cognitive deficit in Parkinson�s disease has been traditionally considered as being mainly related to executive dysfunction secondary to frontostriatal affectation. However, this traditional consideration has recently been challenged. Forty-three nondemented PD patients (mean age = 59.19; SD = 9.64) and twenty control group subjects (mean age = 60.85; SD = 12.26) were studied. They were assessed on a wide range of cognitive functions. Patients showed motor slowing (p = .012), along with alterations in visuoperceptive (p = .001), visuospatial (p = .007) and visuoconstructive functions (p = .017), as well as in visual span (direct: p = .008; inverse: p = .037). Regarding executive functions, differences were not observed in classical measures for verbal fluency (phonetic: p = .28; semantic: p = .27) or in response inhibition (Stroop test: p = .30), while execution was altered in other prefrontal tasks (Wisconsin Test: p = .003; action fluency: p = .039). Patients showed altered performance in verbal learning processes (p = .005) and delayed memory (free: p = .032; cued: p = .006), visuospatial learning (p = .016) and linguistic functions (naming: p < .001; comprehension: p = .007). Poor performance in visuospatial memory is predicted by deficits in working memory and visuospatial perception. Taken together, the observed alterations not only suggest prefrontal affectation, but also temporal and parietal systems impairment. Thus, cognitive dysfunction in nondemented PD patients cannot be exclusively explained by frontostriatal circuit affectation and the resulting executive dysfunction.

Références bibliographiques

  • Apostolova L., Alves G., Hwang K. S., Babakchanian S., Bronnick K. S., Larsen J. P., M. K Beyer. (2012). Hippocampal and ventricular change s in Parkinson's disease mild cognitive impairment. Neurobiology of Aging, 33, 2113-2124. http://dx.doi.org/10.1016/j.neurobiolaging.2011.06.014
  • Barbizet J., & Cany E. (1968). Clinical and psychometrical study of a patient with memory disturbances. International Journal of Neurology, 7, 44-54.
  • Barone P., Aarsland D., Burn D., Em re M., Kulisevsky J., & Weintraub D. (2011). Cognitive impairment in nondemented Parkinson's disease. Movement Disorders, 26, 2483-2495. http://dx.doi.org/10.1002/mds.23919.
  • Beck A. T., Ward C. H., Mendelson M., Mock J., & Erbaugh J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571. http://dx.doi.org/10.1001/archpsyc.1961.01710120031004 .
  • Benton A. L., & Hamsher K. (1989). Multilingual aphasia examination (2nd Ed.). Iowa City, IA: Department of Neurology and Psychology. The University of Iowa.
  • Benton A. L., Hamsher K. S., Varney N. R., & Spreen O. (1983). Contributions of the neuropsychological assessment: A clinical manual. New York: Oxford University Press.
  • Bertella L., Albani G., Greco E., Priano L., Mauro A., Marchi S., ⋯ Semenza C. ( 2002). Noun verb dissociation in Parkinson's disease. Brain and Cognition, 48, 277-280.
  • Beyer M. K., Bronnick K. S., Hwang K. S., Bergsland N., Tysnes O. B., Larsen J. P., Apostolova L. G. (2013).Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 84, 23-28. http://dx.doi.org/10.1136/jnnp-2012-303054.
  • Blesa R., Pujol M., Aguilar M., Santacruz P., Bertran-Serra I., Hernández G., ⋯ NORMACODEM Group (2001 Clinical validity of t he mini-mental state for Spanish speaking communities. Neuropsychologica, 39, 1150-1157. http://dx.doi.org/10.1016/S0028-3932(01)00055-0
  • Braak H., Rüb U., & Del Tredici K. (2006). Cognitive de cline correlates with neuropathological stage in Parkinson's disease. Journal of the Neurological Sciences, 248, 255-258. http://dx.doi.org/10.1016/j.jns.2006.05.011 .
  • Brand M.,Labudda K.,Kalbe E.,Hilker R.,Emmans D.,Fuchs G.,Markowitscha H. J. 2004 Decision-making impairments in patients with Parkinson's disease Behavioral Neurology 15 77-85 http://dx.doi.org/10.1155/2004/578354
  • Cab allol N., Marti M. J., & Tolosa E. (2007). Cognitive dysfunction and dementia in Parkinson disease. Movement Disorders, 22, 358-366. http://dx.doi.org/10.1002/mds.21677.
  • Cotelli M., Borroni B., Manenti R., Zanetti M., Arevalo A., Cappa S. F., ⋯ Padovani A. (2007). Action and object naming in Parkinson's disease without dementia. European Journal of Neurology, 14, 632-637. http://dx.doi.org/10.1111/j .1468-1331.2007.01797.x
  • Cuetos F., Ellis A., & Álvarez B. (1999). Naming times for the Snodgrass and Vanderwart pictures in Spanish. Behavior, Research, Methods, Instruments, & Computers, 31, 650-658. http://dx.doi.org/10.3758/BF03200741
  • Delis D. C., Kramer J. H., Kaplan E., & Ober B. A. (1987). California Verbal Learning Test. Research edition manual. New York, NY: Psychological Corporation.
  • Druks J., & Masterson J. (2000). Object and action naming batter. Hove, UK: Psychology Press.
  • Dubois B., Burn D., Goetz C., Aarsland D., Brown R. G., Broe G. A., ⋯ Emre M. (2007). Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force. Movement disorders, 22, 2314-2324. http://dx.doi.org/10.1002/mds.21844
  • Emre M., Aarsland D., Brown R., Burn D. J., Duyckaerts C., Mizuno Y., Dubois B. (2007) Clinical diagnostic criteria for dementia associated with Parkinson's Disease. Movement Disorders, 22, 1689-1707. http://dx.doi.org/10.10 02/mds.21507.
  • Fahn S., & Elton R. L. (1987). Unified Parkinson's Disease Rating Scale. In: S. Fahn, C. D. Marsden, M. Goldstein, & D. B. Calne (Eds.), Recent developments in Parkinson's disease. (pp. 153-163). New York, NY: Macmillan.
  • Galtier I., Nieto A., Barroso J., & Lorenzo J. N. (2009). Visuospatial learning impairment in Parkinson disease. Psicothema, 21, 21-26.
  • Golden C. J. (1978). Stroop color and word test. A manual for clinical and experimental uses. Illinois, IL: Stoelting Company.
  • Gronwall D. M. (1977). Paced auditory serial-Addition task: A measure of recovery from concussion. Pe rceptual & Motor Skills, 44, 367-373. http://dx.doi.org/10.2466/pms.1977.44.2.367
  • Grossman M. (1999). Sentence processing in Parkinson's disease. Brain and Cognition, 40, 387-413. http://dx.doi.org/10.1006/brcg.1999.1087
  • Grossman M., Carvell S., Stern M. B., Gollomp S., & Hurtig H. I. (1992). Sentence comprehension in Parkinson's disease: The role of attention and memory. Brain and Language , 42, 347-384. http://dx.doi.org/10.1016/0093-934X(92)90074-O
  • Heaton R. K. (1981). Wisconsin Card Sorting Test manual. Odessa: FL: Psychological assessment resources.
  • Higginson C. I., Wheelock V. L., Carroll K. E., & Sigvardt K. A. (2005). Recognition memory in Parkinson's disease with and without dementia: Evidence inconsistent with the retrieval deficit hypothesis. Journal of Clinical and Experimental Ne uropsychology, 27, 516-528. http://dx.doi.org/10.1080/13803390490515469
  • Hochstadt J., Nakano H., Lieberman P., & Friedman J. (2006). The roles of sequencing and verbal working memory in sentence com prehension deficits in Parkinson's disease. Brain and Language, 97, 243-257. http://dx.doi.org/10.1016/j.bandl.2005.10.011
  • Hoehn M. M., & Yahr M. D. (1967). Parkinsonism: Onset, progression and mortality. Neurology, 17, 427-442. http://dx.doi.org/10.1212/WNL.17.5.427
  • Hughes A. J., Daniel S. E., Kilford L., & Lees A. J. (1992). Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases. Journal of Neurology, Neurosurgery, and Psychiatry, 55, 181-184. http://dx.doi.org/10.1136/jnnp.55.3.181
  • Ibarretxe-Bilbao N., Tolosa E., Junque C., & Marti M. J. (2009). MRI and cognitive impairment in Parkinson's disease. Movement Disorders, 24, 748-753. http://dx.doi.org/10.1002/mds.22670.
  • Jokinen P., Bruck A., Aalto S., Forsback S., Parkkola R., & Rinne J. O. (2009). Impaired cognitive performance in Parkinson's disease is related to caudate dopaminergic hypofunction and hippocampal atrophy. Parkinsonism & Related Disorders, 15, 88-93. http://dx.doi.org/10.1016/j.parkreldis.2008.03.005.
  • Lees A. J.,Smith E. 1983 Cognitive deficits in the early stages of Parkinson's disease Brain 106 257-270, http://dx.doi.org/10.1093/brain/106.2.257
  • Liozidou A., Potagas C., Papageorgiou S. G., & Zalonis I. (2012). The role of working memory and information processing speed on Wisconsin Card Sorting Test performance in Parkinson disease without dementia. Journal of Geriatric Psychiatry and Neurology, 25, 215-221. http://dx.doi.org/10.1177/0891988712466456
  • Muslimovic D., Post B., Speelman J. D., & Schmand B. (2007). Motor procedural learning in Parkinson's disease. Brain, 130, 2887-2897. http://dx.doi.org/10.1093/brain/awm211
  • Obeso I., Casabona E., Bringas M. L., Alvarez L., & Jahanshahi M. (2012). Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables. Behavioural Neurology, 25, 111-118. http://dx.doi.org/10.1155/2012/673610
  • Pereira J. B., Junque C., Marti M. J., Ramirez-Ruiz B., Bargallo N., & Tolosa E. (2009). Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease. Movement Disorders, 24, 1193-1 199. http://dx.doi.org/10.1002/mds.22560
  • Piatt A. L., Fields J. A., Paolo A. M., Koller W. C., & Troster A. I. (1999) Lexical, semantic, and action verbal fluency in Parkinson's disease with and without deme ntia. Journal of Clinical and Experimental Neuropsychology, 21, 435-443. http://dx.doi.org/10.5555/jcen.21.4.435.885
  • Piatt A. L., Fields J. A., Paolo A. M., & Troster A. I. (1999). Action (verb naming) fluency as an executive function measure: Convergent and divergent evidence of validity. Neuropsychologia, 37, 1499-1503. http://dx.doi.org/10.1016/S0028-3932(99)00066-4
  • Pillon B., Deweer B., Agid Y., & Dubois B. (1993). Explicit memory in Alzheimer's, Huntington's, and Parkinson's diseases. Archives of Neurology, 50, 374-379. http://dx.doi.org/10.1001/archneur.1993.00540040036010
  • Rodriguez-Ferrei ro J., Menendez M., Ribacoba R., & Cuetos F. (2009). Action naming is impaired in Parkinson disease patients. Neuropsychologia, 47, 3271-3274. http://dx.doi.org/10.1016/j.neuropsychologia.2009.07.007
  • Schneider J. S. (2007). Behavioral persistence deficit in Parkinson's disease patients. European Journal of Neurology, 14, 300-304. http://dx.doi.org/10.1111/j.1468-1331. 2006.01647.x
  • Schuhfr ied G. (1992). Vienna reaction unit (manual). Vienna, Austria: Schuhfried Ges.m.b.H.
  • Signorini M., & Volpato C. (2006). Action fluency in Parkinson's disease: A follow-up study. Movement Disorders, 21, 467-472. http://dx.doi.org/10.1002/mds.20718.
  • Skeel R. L., Crosson B., Nadeau S. E., Algina J., Bauer R. M., & Fennell E. B. (2001). Basal ganglia dysfunction, working memory, and sentence comprehension in patients with Parkinson's disease. Neuropsychologia, 39, 962-971. http://dx.doi.org/10.1016/S0028-3932(01)00026-4
  • Stefanova E. D., Kostic V. S., Ziropadja L. J., Ocic G. G., & Markovic M. (2001). Declarative memory in early Parkinson's disease: Serial po sition learning effects. Journal of Clinical and Experimental Neuropsychology, 23, 581-591. http://dx.doi.org/10.1076/jcen.23.5.581.1239
  • Tröster A. I., & Fields J. A. (2005). Frontal cognitive function and memory in Parkinson's disease: Toward a distinction between prospective and declarative memory impairments. Behavioral Neurology, 8, 59-74. http://dx.doi.org/10.3233/BEN-1995-8201
  • Uc E. Y., Rizzo M., Ander son S. W., Qian S., Rodnitzky R. L., & Dawson J. D. (2005). Visual dysfunction in Parkinson disease without dementia. Neurology, 65, 1907-1913. http://dx.doi.org/10.1212/01.wnl.0000191565. 11065.11.
  • Wechsler D. (1997 a ). Wechsler Adult Intelligence Scale (3rd Ed.). Administration and scoring manual. San Antonio, TX: The Psychological Corporation.
  • Wechsler D. (1997 b). Wechsler Memory Scale (3rd Ed.). Technic al manual. San Antonio, TX: The Psychological Corporation.
  • Whittington C. J., Podd J., & Stewart-Williams S. (2006). Memory deficits in Parkinson's disease. Journal of Clinical and Experimental Neuropsychology , 28, 738-754. http://dx.doi.org/10.1080/13803390590954236.
  • Witt K., Nuhsman A., & Deuschl G. (2002). Dissociation of habit-learning in Parkinson's and cerebellar disease. Journal of cognitive neu roscience, 14, 493-499. http://dx.doi.org/10.1162/089892902317362001.