Cognitive Impairment in Parkinson's DiseaseMore than a Frontostriatal Dysfunction

  1. Galtier Hernández, Iván
  2. Nieto Barco, María Antonieta
  3. Lorenzo, Jesús Norelis
  4. Barroso Ribal, José
Revista:
The Spanish Journal of Psychology

ISSN: 1138-7416

Ano de publicación: 2014

Volume: 17

Páxinas: 1-8

Tipo: Artigo

DOI: 10.1017/SJP.2014.69 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: The Spanish Journal of Psychology

Obxectivos de Desenvolvemento Sustentable

Resumo

Cognitive deficit in Parkinson�s disease has been traditionally considered as being mainly related to executive dysfunction secondary to frontostriatal affectation. However, this traditional consideration has recently been challenged. Forty-three nondemented PD patients (mean age = 59.19; SD = 9.64) and twenty control group subjects (mean age = 60.85; SD = 12.26) were studied. They were assessed on a wide range of cognitive functions. Patients showed motor slowing (p = .012), along with alterations in visuoperceptive (p = .001), visuospatial (p = .007) and visuoconstructive functions (p = .017), as well as in visual span (direct: p = .008; inverse: p = .037). Regarding executive functions, differences were not observed in classical measures for verbal fluency (phonetic: p = .28; semantic: p = .27) or in response inhibition (Stroop test: p = .30), while execution was altered in other prefrontal tasks (Wisconsin Test: p = .003; action fluency: p = .039). Patients showed altered performance in verbal learning processes (p = .005) and delayed memory (free: p = .032; cued: p = .006), visuospatial learning (p = .016) and linguistic functions (naming: p < .001; comprehension: p = .007). Poor performance in visuospatial memory is predicted by deficits in working memory and visuospatial perception. Taken together, the observed alterations not only suggest prefrontal affectation, but also temporal and parietal systems impairment. Thus, cognitive dysfunction in nondemented PD patients cannot be exclusively explained by frontostriatal circuit affectation and the resulting executive dysfunction.

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