Estudio comparativo del control colinérgico y serotonérgico sobre los procesos neurofisiológicos involucrados en el ciclo sueño-vigilia
- Tejada Gavela, Silvia
- Susana Cristina Esteban Valdés Director
- Antonio Gamundí Gamundí Co-director
Defence university: Universitat de les Illes Balears
Fecha de defensa: 03 December 2010
- Rubén Víctor Rial Planas Chair
- Maria Cristina Nicolau Llobera Secretary
- Mourad Akaârir El Ghourri Committee member
- Julián Jesús González González Committee member
- Antonius M. L Coenen Committee member
Type: Thesis
Abstract
We analyzed the control of cholinergic and serotonergic systems on sleep-wake cycle of rat and ring dove. We examined the EEG pattern, especially the theta rhythm, locomotor activity, cognitive function and brain oxidative stress. The cholinergic agonist pilocarpine increased the rhythm and power of the theta band during waking in cortex, accompanied by hippocampal theta rhythm, indicating an increase in the transfer of information to the cortex that correlated with increased cognitive abilities without altering the oxidative status brain. Moreover, we studied the role of serotonin (5-HT) in the sleep-wake cycle in birds compared with the known in mammals. The 5-HT1A agonist 8-OH-DPAT increased locomotor activity and active waking, decreasing sleep. The 5-HT depletion caused the opposite, reflecting a stimulatory effect of 5-HT on active waking, and inhibition of sleep, through the 5-HT1A receptor, as