Antiproliferative Activity of Three Wild Growing Species in Tunisia: Nicotiana Glauca, Artemisia Campestris and Astragalus Gombo

  1. José M. Padrón 1
  2. Hassen Teyeb 2
  3. Wahiba Douki 2
  1. 1 BioLab. Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain
  2. 2 Biochemistry and Toxicology Laboratory, University Hospital of Monastir, Av. Juin 02, Monastir 5000, Tunisia
Revista:
International Journal of Pharmacognosy
  1. Dr. Shashi Alok (ed. lit.)

ISSN: 2348-3962,  2394-5583

Año de publicación: 2017

Volumen: 4

Número: 9

Páginas: 294-298

Tipo: Artículo

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Otras publicaciones en: International Journal of Pharmacognosy

Resumen

Tunisian flora contains several wild plants with diverse therapeutic uses. As a contribution to the efforts to select natural sources of antitumor compounds, we investigated in this study the antiproliferative activity of several extracts of the Tunisian species: Astragalus gombo, Nicotiana glauca and Artemisia campestris. Dried aerial part (A. gombo and A. campestris) and leaves (N. glauca) were extracted with ethyl acetate, dichloromethane, and methanol. In the vitro anti-proliferative activity of the extracts was tested against the human solid tumor cell lines: HBL-100, T-47D, and WiDr. Tests were performed using the sulforhodamine B (SRB) assay. All extracts of A. campestris and A. gombo were active against all tested cell lines, with GI50 values between 12 and 93 μg/ml. Dichloromethane extract of A. campestris was the most active extract with GI50 of 12 μg/ml against HBL-100 cell line. This kind of cell seems to be the most sensitive regarding all tested extracts. Our results showed that A. gombo, A. campestris and N. glauca are a promising source of natural antitumor compounds. More detailed studies should be conducted especially for most active extracts.

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