Random Lasing Detection of Mutant Huntingtin Expression in Cells

  1. Fumagallo-Reading, Felipe 1
  2. González-Hernández, Tomás 1
  3. Lahoz, Fernando 1
  4. de Armas-Rillo, Sergio 1
  5. Luis-Ravelo, Diego 1
  6. Abdul-Jalbar, Beatriz 1
  1. 1 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    ROR https://ror.org/01r9z8p25

Journal:
Sensors

ISSN: 1424-8220

Year of publication: 2021

Volume: 21

Issue: 11

Pages: 3825

Type: Article

DOI: 10.3390/S21113825 GOOGLE SCHOLAR

More publications in: Sensors

Metrics

Cited by

  • Scopus Cited by: 4 (16-01-2023)
  • Web of Science Cited by: 3 (04-01-2023)

JCR (Journal Impact Factor)

  • Year 2021
  • Journal Impact Factor: 3.847
  • Journal Impact Factor without self cites: 3.19
  • Article influence score: 0.586
  • Best Quartile: Q2
  • Area: CHEMISTRY, ANALYTICAL Quartile: Q2 Rank in area: 29/87 (Ranking edition: SCIE)
  • Area: INSTRUMENTS & INSTRUMENTATION Quartile: Q2 Rank in area: 19/64 (Ranking edition: SCIE)
  • Area: ENGINEERING, ELECTRICAL & ELECTRONIC Quartile: Q2 Rank in area: 95/276 (Ranking edition: SCIE)

SCImago Journal Rank

  • Year 2021
  • SJR Journal Impact: 0.803
  • Best Quartile: Q1
  • Area: Analytical Chemistry Quartile: Q1 Rank in area: 27/124
  • Area: Instrumentation Quartile: Q1 Rank in area: 25/139
  • Area: Biochemistry Quartile: Q2 Rank in area: 169/439
  • Area: Information Systems Quartile: Q2 Rank in area: 106/352
  • Area: Electrical and Electronic Engineering Quartile: Q2 Rank in area: 178/730
  • Area: Medicine (miscellaneous) Quartile: Q2 Rank in area: 690/2489
  • Area: Atomic and Molecular Physics, and Optics Quartile: Q2 Rank in area: 50/198

Scopus CiteScore

  • Year 2021
  • CiteScore of the Journal : 6.4
  • Area: Instrumentation Percentile: 91
  • Area: Electrical and Electronic Engineering Percentile: 81
  • Area: Atomic and Molecular Physics, and Optics Percentile: 79
  • Area: Analytical Chemistry Percentile: 79
  • Area: Information Systems Percentile: 78
  • Area: Biochemistry Percentile: 66

Journal Citation Indicator (JCI)

  • Year 2021
  • Journal Citation Indicator (JCI): 0.9
  • Best Quartile: Q1
  • Area: INSTRUMENTS & INSTRUMENTATION Quartile: Q1 Rank in area: 16/76
  • Area: CHEMISTRY, ANALYTICAL Quartile: Q1 Rank in area: 24/99
  • Area: ENGINEERING, ELECTRICAL & ELECTRONIC Quartile: Q2 Rank in area: 109/344

Abstract

Huntington’s disease (HD) is an autosomal dominant, incurable neurodegenerative disease caused by mutation in the huntingtin gene (HTT). HTT mutation leads to protein misfolding and aggregation, which affect cells’ functions and structural features. Because these changes might modify the scattering strength of affected cells, we propose that random lasing (RL) is an appropriate technique for detecting cells that express mutated HTT. To explore this hypothesis, we used a cell model of HD based on the expression of two different forms—pathogenic and non-pathogenic—of HTT. The RL signals from both cell profiles were compared. A multivariate statistical analysis of the RL signals based on the principal component analysis (PCA) and linear discriminant analysis (LDA) techniques revealed substantial differences between cells that expressed the pathogenic and the non-pathogenic forms of HTT.

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