NMDA receptor–BK channel coupling regulates synaptic plasticity in the barrel cortex

  1. Gómez, Ricardo 1
  2. Maglio, Laura E. 1
  3. Gonzalez-Hernandez, Alberto J. 1
  4. Rivero-Pérez, Belinda 1
  5. Bartolomé-Martín, David 1
  6. Giraldez, Teresa 1
  1. 1 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    ROR https://ror.org/01r9z8p25

Journal:
Proceedings of the National Academy of Sciences

ISSN: 0027-8424

Year of publication: 2021

Volume: 118

Issue: 35

Pages: e2107026118

Type: Article

DOI: 10.1073/PNAS.2107026118 GOOGLE SCHOLAR

More publications in: Proceedings of the National Academy of Sciences

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Metrics

Cited by

  • Scopus Cited by: 11 (02-06-2023)
  • Web of Science Cited by: 9 (06-06-2023)
  • Dimensions Cited by: 7 (09-03-2023)

JCR (Journal Impact Factor)

  • Year 2021
  • Journal Impact Factor: 12.779
  • Journal Impact Factor without self cites: 12.526
  • Article influence score: 4.658
  • Best Quartile: Q1
  • Area: MULTIDISCIPLINARY SCIENCES Quartile: Q1 Rank in area: 9/74 (Ranking edition: SCIE)

SCImago Journal Rank

  • Year 2021
  • SJR Journal Impact: 4.184
  • Best Quartile: Q1
  • Area: Multidisciplinary Quartile: Q1 Rank in area: 4/150

CIRC

  • Social Sciences: A+
    •

Scopus CiteScore

  • Year 2021
  • CiteScore of the Journal : 18.1
  • Area: Multidisciplinary Percentile: 95

Journal Citation Indicator (JCI)

  • Year 2021
  • Journal Citation Indicator (JCI): 2.62
  • Best Quartile: Q1
  • Area: MULTIDISCIPLINARY SCIENCES Quartile: Q1 Rank in area: 10/135

Dimensions

(Data updated as of 09-03-2023)
  • Total citations: 7
  • Recent citations: 7
  • Relative Citation Ratio (RCR): 0.92
  • Field Citation Ratio (FCR): 4.85

Abstract

Postsynaptic N-methyl-D-aspartate receptors (NMDARs) are crucial mediators of synaptic plasticity due to their ability to act as coincidence detectors of presynaptic and postsynaptic neuronal activity. However, NMDARs exist within the molecular context of a variety of postsynaptic signaling proteins, which can fine-tune their function. Here, we describe a form of NMDAR suppression by large-conductance Ca2+- and voltage-gated K+ (BK) channels in the basal dendrites of a subset of barrel cortex layer 5 pyramidal neurons. We show that NMDAR activation increases intracellular Ca2+ in the vicinity of BK channels, thus activating K+ efflux and strong negative feedback inhibition. We further show that neurons exhibiting such NMDAR–BK coupling serve as high-pass filters for incoming synaptic inputs, precluding the induction of spike timing–dependent plasticity. Together, these data suggest that NMDAR-localized BK channels regulate synaptic integration and provide input-specific synaptic diversity to a thalamocortical circuit.

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