G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal Myometrium and Uterine Leiomyoma

  1. Fernández LH 1
  2. Rodríguez del Río M 1
  3. Reyes R. 1
  4. Bello A.R. 1
  1. 1 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    ROR https://ror.org/01r9z8p25

Revista:
Cell & Cellular Life Sciences Journal

ISSN: 2578-4811

Año de publicación: 2021

Volumen: 6

Número: 2

Tipo: Artículo

GOOGLE SCHOLAR

Otras publicaciones en: Cell & Cellular Life Sciences Journal

Resumen

Uterine leiomyomas are the most common benign smooth muscle tumours of the female reproductive system. Theirpathogenesis is unclear but they are known to be sensitive to sex hormones, estrogens and progesterone, which influencetheir behaviour and evolution. The action of estrogens depends on the presence of certain receptors in the cell, includingG-protein-coupled estrogen membrane receptor, GPER. In this work, using immunohistochemical techniques, we studied thepresence of GPER in samples of typical uterine leiomyomas and paired myometrium as well as in fast-growing leiomyomas.The results show the presence of GPER in both uterine tissues with a different subcellular distribution, being the most frequentnucleic location in myometrium, and the most frequent cytoplasmic location in leiomyoma. Likewise, we observed that in fastgrowing leiomyomas, the cytoplasmic location is even more abundant than in typical leiomyomas. In conclusion, these dataseem to suggest that GPER could be involved in certain actions of estrogens related to the pathogenesis and behaviour of thesetumours.

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