Perfil y endofenotipos neuropsicológicos en TDAH:Una revisión

  1. Belén Rubio 1
  2. Jennifer Castrillo 2
  3. Oscar Herreros 3
  4. Xavier Gastaminza 4
  5. Sergio Hernández 1
  1. 1 Facultativo especialista de Psiquiatría. Unidad de Interconsulta y Enlace de Psiquiatría Infanto-Juvenil, Hospital Universitario de Canarias, La Laguna
  2. 2 Psicóloga. Dpto. Psicología Clínica, Psicobiología y Metodología. Facultad de Ciencias de la Salud Sección de Psicología, Universidad de La Laguna
  3. 3 Facultativo especialista del Área de Psiquiatría. Uni-dad de Salud Mental Infanto-Juvenil. Complejo Hospita-lario Universitario de Granada
  4. 4 Facultativo especialista de Psiquiatría. NOVOME-DIGRUP. Paidopsiquiatría psicosomática. Unidad de Paidopsiquiatría. Hospital Universitari Vall d’Hebron, Barcelona. Universitat Autonoma de Barcelona
  5. 5 Profesor Titular. Dpto. Psicología Clínica, Psi-cobiología y Metodología. Facultad de Ciencias de la Salud, Sección de Psicología, Universidad de La Laguna
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Journal:
Revista de Psiquiatría Infanto-Juvenil

ISSN: 2660-7271,  1130-9512

Year of publication: 2016

Volume: 33

Issue: 1

Pages: 7-20

Type: Article

DOI: 10.31766/REVPSIJ.V33N1A1 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Revista de Psiquiatría Infanto-Juvenil

Abstract

There is a generalized scientific agreement that a high percentage of people with attention deficit hyperactivity disorder (ADHD) also show significant difficulties in neuropsychological performance. There is evidence for both cognitive-behavioral and neurophysiological data. Deficits in executive functioning have been widely observed in ADHD and robust effect sizes for working memory and inhibition are found. In this work, we show a review of the most common neuropsychological profile found in ADHD, and discuss the explanatory models and the difficulties with neuropsychological endophenotypes.

Bibliographic References

  • Catalá-López F, Peiró S, Ridao M, Sanfélix-Gimeno G, Gènova-Maleras R, Catalá MA. Prevalence of attention deficit hyperactivity disorder among children and adolescents in Spain: a systematic review and meta-analysis of epidemiological studies. BMC Psychiatry 2012; 12: 168.
  • A.Willcutt EG. The prevalence of DSM-IV attention-deficit/ hyperactivity disorder: a metaanalytic review. Neurotherapeutics 2012; 9: 490-9.
  • Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke EJS. Causal heterogeneity in attentiondeficit/ hyperactivity disorder: Do we need neuropsychologically impaired subtypes? Biol Psychiatry 2005; 57: 1224-1230.
  • Crosbie J, Pérusse D, Barr CL, Schachar RJ. Validating psychiatric endophenotypes: inhibitory control and attention deficit hyperactivity disorder. Neurosci Biobehav Rev 2008; 32: 40-55.
  • Rapport MD, Alderson RM, Kofler MJ, Sarver DE, Bolden J, Sims V. Working memory deficits in boys with attention-deficit/hyperactivity disorder (ADHD): The contribution of central executive and subsystem processes. J Abnorm Child Psychol 2008; 36: 825-837.
  • Sonuga-Barke EJS, Sergeant J a., Nigg J, Willcutt E. Executive Dysfunction and Delay Aversion in Attention Deficit Hyperactivity Disorder: Nosologic and Diagnostic Implications. Child Adolesc Psychiatr Clin N Am 2008; 17: 367-384.
  • Baddeley A. The fractionation of working memory. Proc Natl Acad Sci USA 1996; 93: 13468-13472.
  • Baddeley A. Working memory: theories, models, and controversies. Annu Rev Psychol 2012; 63: 1-29.
  • Cowan N. Visual and auditory working memory capacity. Trends Cogn Sci 1998; 2: 77.
  • Posner MI. Attention: the mechanisms of consciousness. Proc Natl Acad Sci USA 1994; 91: 7398-7403.
  • Comoldi C, Barbieri A, Gaiani C, Zocchi S. Strategic memory deficits in attention deficit disorder with hyperactivity participants: The role of executive processes. Dev Neuropsychol 1999; 15: 53-71.
  • Ott DA, Lyman RD. Automatic and Effortful Memory in Children Exhibiting Attention-Deficit Hyperactivity Disorder. J Clin Child Psychol 1993; 22: 420-427
  • Douglas VI, Benezra E. Supraspan verbal memory in attention deficit disorder with hyperactivity normal and reading-disabled boys. J Abnorm Child Psychol 1990; 18: 617-638.
  • Cahn DA, Marcotte AC. Rates of forgetting in attention deficit hyperactivity disorder. Child Neuropsychol 1995; 1: 158-163.
  • Denckla MB. ADHD: Topic update. Brain Dev 2003; 25: 383-389.
  • Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 1997; 121: 65-94.
  • Willcutt EG, Doyle AE, Nigg JT, Faraone S V, Pennington BF. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry 2005; 57: 1336-1346.
  • Chhabildas N, Pennington BF, Willcutt EG. A comparison of the neuropsychological profiles of the DSM-IV subtypes of ADHD. J Abnorm Child Psychol 2001; 29: 529-540.
  • Shanahan MA, Pennington BF, Yerys BE, et al. Processing speed deficits in attention deficit/ hyperactivity disorder and reading disability. J Abnorm Child Psychol 2006; 34: 585-602.
  • Rucklidge JJ, Tannock R. Neuropsychological profiles of adolescents with ADHD: effects of reading difficulties and gender. J Child Psychol Psychiatry 2002; 43: 988-1003.
  • Cole WR, Mostofsky SH, Larson JCG, Denckla MB, Mahone EM. Age-related changes in motor subtle signs among girls and boys with ADHD. Neurology 2008; 71: 1514-1520.
  • Mahone EM, Mostofsky SH, Lasker AG, Zee D, Denckla MB. Oculomotor Anomalies in Attention-Deficit/Hyperactivity Disorder: Evidence for Deficits in Response Preparation and Inhibition. J Am Acad Child Adolesc Psychiatry 2009; 48: 749-756.
  • Mostofsky SH, Simmonds DJ. Response inhibition and response selection: two sides of the same coin. J Cogn Neurosci 2008; 20: 751-761.
  • Sesma HW, Mahone EM, Levine T, Eason SH, Cutting LE. The contribution of executive skills to reading comprehension. Child Neuropsychol 2009; 15: 232-246.
  • Jacobson LA, Ryan M, Martin RB, et al. Working memory influences processing speed and reading fluency in ADHD. Child Neuropsychol 2011; 17: 209-224.
  • Eslinger PJ. Conceptualizing, describing, and measuring components of executive function: A summary. In: Attention, Memory, and Executive Function; 1996: 367-395.
  • Lezak MD, Howieson DB, Loring DW, Hannay HJ, Fischer JS. Neuropsychological Assessment (4th Ed.); 2004.
  • Tekin S, Cummings JL. Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J Psychosom Res 2002; 53: 647-654.
  • Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends Cogn Sci 2004; 8: 170-177.
  • Posner MI. Attentional networks and consciousness. Front Psychol 2012; 3: 64.
  • Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci 2001; 24: 167-202.
  • RUSHWORTH M, WALTON M, KENNERLEY S, BANNERMAN D. Action sets and decisions in the medial frontal cortex. Trends Cogn Sci 2004; 8: 410-417.
  • Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 2002; 3: 201-215.
  • Botvinick M, Braver T. Motivation and Cognitive Control: From Behavior to Neural Mechanism. Annu Rev Psychol 2014; 66: 83-113.
  • Paxton JL, Barch DM, Racine CA, Braver TS. Cognitive control, goal maintenance, and prefrontal function in healthy aging. Cereb Cortex 2008; 18: 1010-1028.
  • Fair DA, Nigg JT, Iyer S, et al. Distinct neural signatures detected for ADHD subtypes after controlling for micro-movements in resting state functional connectivity MRI data. Front Syst Neurosci 2013; 6: 80.
  • Nelson SM, Dosenbach NUF, Cohen AL, Wheeler ME, Schlaggar BL, Petersen SE. Role of the anterior insula in task-level control and focal attention. Brain Struct Funct 2010; 214: 669-680.
  • Bunge SA, Wright SB. Neurodevelopmental changes in working memory and cognitive control. Curr Opin Neurobiol 2007; 17: 243-250.
  • Daigneault S, Braün CM, Whitaker HA. An empirical test of two opposing theoretical models of prefrontal function. Brain Cogn 1992; 19: 48-71.
  • Scheres A, Oosterlaan J, Geurts H, et al. Executive functioning in boys with ADHD: Primarily an inhibition deficit? Arch Clin Neuropsychol 2004; 19: 569-594.
  • Geurts HM, Verté S, Oosterlaan J, Roeyers H, Sergeant J a. ADHD subtypes: Do they differ in their executive functioning profile? Arch Clin Neuropsychol 2005; 20: 457-477.
  • Stuss DT. Biological and psychological development of executive functions. Brain Cogn 1992; 20: 8-23.
  • Klenberg L, Korkman M, Lahti-Nuuttila P. Differential development of attention and executive functions in 3- to 12-year-old Finnish children. Dev Neuropsychol 2001; 20: 407-428.
  • Vaidya CJ, Stollstorff M. Cognitive neuroscience of Attention Deficit Hyperactivity Disorder: current status and working hypotheses. Dev Disabil Res Rev 2008; 14: 261-267.
  • Nigg JT. Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: The state of the field and salient challenges for the coming decade. Biol Psychiatry 2005; 57: 1424-1435.
  • Castellanos FX, Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 2002; 3: 617-628.
  • Durston S, Mulder M, Casey BJ, Ziermans T, van Engeland H. Activation in Ventral Prefrontal Cortex is Sensitive to Genetic Vulnerability for Attention-Deficit Hyperactivity Disorder. Biol Psychiatry 2006; 60: 1062-1070.
  • Casey BJ, Durston S. From behavior to cognition to the brain and back: what have we learned from functional imaging studies of attention deficit hyperactivity disorder? Am J Psychiatry 2006; 163: 957-960.
  • Mennes M, Vega Potler N, Kelly C, Di Martino A, Castellanos FX, Milham MP. Resting State Functional Connectivity Correlates of Inhibitory Control in Children with Attention-Deficit/ Hyperactivity Disorder. Front Psychiatry 2012; 2: 83.
  • Aron AR. From reactive to proactive and selective control: developing a richer model for stopping inappropriate responses. Biol Psychiatry 2011; 69: e55-e68.
  • Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex: one decade on. Trends Cogn Sci 2014; 18: 177-185.
  • Seidman LJ. Neuropsychological functioning in people with ADHD across the lifespan. Clin Psychol Rev 2006; 26: 466-485.
  • Pasini A, Paloscia C, Alessandrelli R, Porfirio MC, Curatolo P. Attention and executive functions profile in drug naive ADHD subtypes. Brain Dev 2007; 29: 400-408.
  • Goldman-Rakic PS. Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates. Prog Brain Res 1990; 85: 325-335.
  • Fuster JM. Network memory. Trends Neurosci 1997; 20: 451-459.
  • Goldman-Rakic PS. Cellular basis of working memory. Neuron 1995; 14: 477-485.
  • Barkley R a, Edwards G, Laneri M, Fletcher K, Metevia L. Executive functioning, temporal discounting, and sense of time in adolescents with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). J Abnorm Child Psychol 2001; 29: 541-556.
  • Kessler RC, Adler L a., Barkley R, et al. Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: Results from the national comorbidity survey replication. Biol Psychiatry 2005; 57: 1442-1451.
  • Frazier TW, Demaree H a, Youngstrom E a. Metaanalysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder. Neuropsychology 2004; 18: 543-555.
  • Alderson RM, Kasper LJ, Hudec KL, Patros CHG. Attention-deficit/hyperactivity disorder (ADHD) and working memory in adults: a meta-analytic review. Neuropsychology 2013; 27: 287-302.
  • Seidman LJ, Biederman J, Faraone S V, et al. Effects of family history and comorbidity on the neuropsychological performance of children with ADHD: preliminary findings. J Am Acad Child Adolesc Psychiatry 1995; 34: 1015-1024.
  • van Ewijk H, Heslenfeld DJ, Luman M, et al. Visuospatial working memory in ADHD patients, unaffected siblings, and healthy controls. J Atten Disord 2014; 18: 369-378.
  • Dovis S, Van der Oord S, Wiers RW, Prins PJM. ADHD Subtype Differences in Reinforcement Sensitivity and Visuospatial Working Memory. J Clin Child Adolesc Psychol 2015; 44: 859-874.
  • Zakay D. The role of attention in children’s time perception. J Exp Child Psychol 1992; 54: 355-371.
  • Mimura M, Kinsbourne M, O’Connor M. Time estimation by patients with frontal lesions and by Korsakoff amnesics. J Int Neuropsychol Soc 2000; 6: 517-528.
  • Martinussen R, Hayden J, Hogg-Johnson S, Tannock R. A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2005; 44: 377-384.
  • Kasper LJ, Alderson RM, Hudec KL. Moderators of working memory deficits in children with attention-deficit/hyperactivity disorder (ADHD): a meta-analytic review. Clin Psychol Rev 2012; 32: 605-617.
  • Weyandt LL. Executive function in children, adolescents, and adults with attention deficit hyperactivity disorder: introduction to the special issue. Dev Neuropsychol 2005; 27: 1-10.
  • Aman CJ, Roberts RJ, Pennington BF. A neuropsychological examination of the underlying deficit in attention deficit hyperactivity disorder: frontal lobe versus right parietal lobe theories. Dev Psychol 1998; 34: 956-969.
  • Carter CS, Krener P, Chaderjian M, Northcutt C, Wolfe V. Abnormal processing of irrelevant information in attention deficit hyperactivity disorder. Psychiatry Res 1995; 56: 59-70.
  • Pineda D, Ardila A, Rosselli M. Neuropsychological and behavioral assessment of ADHD in seven- to twelve-year-old children: a discriminant analysis. J Learn Disabil 1999; 32: 159-173.
  • Baker SC, Rogers RD, Owen AM, et al. Neural systems engaged by planning: a PET study of the Tower of London task. Neuropsychologia 1996; 34: 515-526.
  • Capilla Gonzalez A, Etchepareborda MC, Fernandez Gonzalez S, et al. [The neurofunctional foundation of cognitive rigidity in attention deficit hyperactivity disorder: some preliminary findings]. Rev Neurol 2004; 38 Suppl 1: S145-S148.
  • Sergeant JA, Geurts H, Oosterlaan J. How specific is a deficit of executive functioning for attentiondeficit/ hyperactivity disorder? Behav Brain Res 2002; 130: 3-28.
  • Rhodes SM, Coghill DR, Matthews K. Neuropsychological functioning in stimulantnaive boys with hyperkinetic disorder. Psychol Med 2005; 35: 1109-1120.
  • Nigg JT, Casey BJ. An integrative theory of attention-deficit/ hyperactivity disorder based on the cognitive and affective neurosciences. Dev Psychopathol 2005; 17: 785-806.
  • Pasini A, Paloscia C, Alessandrelli R, Porfirio MC, Curatolo P. Attention and executive functions profile in drug naive ADHD subtypes. Brain Dev 2007; 29: 400-408.
  • Barkley RA. Advances in the diagnosis and subtyping of attention deficit hyperactivity disorder: what may lie ahead for DSM-V. Rev Neurol 2009; 48 Suppl 2: S101-S106.
  • Antrop I, Stock P, Verté S, Wiersema JR, Baeyens D, Roeyers H. ADHD and delay aversion: the influence of non-temporal stimulation on choice for delayed rewards. J Child Psychol Psychiatry 2006; 47: 1152-1158.
  • Solanto M V, Abikoff H, Sonuga-Barke E, et al. The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: a supplement to the NIMH multimodal treatment study of AD/HD. J Abnorm Child Psychol 2001; 29: 215-228.
  • Sonuga-Barke EJS. Psychological heterogeneity in AD/HD--a dual pathway model of behaviour and cognition. Behav Brain Res 2002; 130: 29-36.
  • Biederman J, Monuteaux MC, Doyle AE, et al. Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in children. J Consult Clin Psychol 2004; 72: 757-766.
  • Luman M, Oosterlaan J, Sergeant J. The impact of reinforcement contingencies on AD/HD: A review and theoretical appraisal. Clin Psychol Rev 2005; 25: 183-213.
  • Rogers RD, Ramnani N, Mackay C, et al. Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition. Biol Psychiatry 2004; 55: 594-602.
  • Cardinal RN. Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core. Science 2001; 292: 2499-2501.
  • Doyle A. Executive functions in attention-deficit/hyperactivity disorder. J Clin Psychiatry 2005; 67 (suppl 8): 21-26.
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