Perfil y endofenotipos neuropsicológicos en TDAH:Una revisión

  1. Belén Rubio 1
  2. Jennifer Castrillo 2
  3. Oscar Herreros 3
  4. Xavier Gastaminza 4
  5. Sergio Hernández 1
  1. 1 Facultativo especialista de Psiquiatría. Unidad de Interconsulta y Enlace de Psiquiatría Infanto-Juvenil, Hospital Universitario de Canarias, La Laguna
  2. 2 Psicóloga. Dpto. Psicología Clínica, Psicobiología y Metodología. Facultad de Ciencias de la Salud Sección de Psicología, Universidad de La Laguna
  3. 3 Facultativo especialista del Área de Psiquiatría. Uni-dad de Salud Mental Infanto-Juvenil. Complejo Hospita-lario Universitario de Granada
  4. 4 Facultativo especialista de Psiquiatría. NOVOME-DIGRUP. Paidopsiquiatría psicosomática. Unidad de Paidopsiquiatría. Hospital Universitari Vall d’Hebron, Barcelona. Universitat Autonoma de Barcelona
  5. 5 Profesor Titular. Dpto. Psicología Clínica, Psi-cobiología y Metodología. Facultad de Ciencias de la Salud, Sección de Psicología, Universidad de La Laguna
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Revista:
Revista de Psiquiatría Infanto-Juvenil

ISSN: 2660-7271,  1130-9512

Año de publicación: 2016

Volumen: 33

Número: 1

Páginas: 7-20

Tipo: Artículo

DOI: 10.31766/REVPSIJ.V33N1A1 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Revista de Psiquiatría Infanto-Juvenil

Resumen

Existe un acuerdo científico generalizado acerca de que un porcentaje elevado de las personas que presentan Trastorno por Déficit de Atención con Hiperactividad (TDAH) tienen también importantes dificultades en su rendimiento psicológico. Esta afirmación cuenta con evidencias cognitivo-conductuales y neurofuncionales. Así, están ampliamente constatados los problemas en el funcionamiento ejecutivo en los pacientes con TDAH, encontrándose, en especial, tamaños de efecto robustos para la memoria de trabajo y la inhibición. En este trabajo se presenta una revisión del perfil neuropsicológico más frecuentemente encontrado en TDAH, y se discuten los distintos modelos explicativos y dificultades en el endofenotipado neuropsicológico.

Referencias bibliográficas

  • Catalá-López F, Peiró S, Ridao M, Sanfélix-Gimeno G, Gènova-Maleras R, Catalá MA. Prevalence of attention deficit hyperactivity disorder among children and adolescents in Spain: a systematic review and meta-analysis of epidemiological studies. BMC Psychiatry 2012; 12: 168.
  • A.Willcutt EG. The prevalence of DSM-IV attention-deficit/ hyperactivity disorder: a metaanalytic review. Neurotherapeutics 2012; 9: 490-9.
  • Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke EJS. Causal heterogeneity in attentiondeficit/ hyperactivity disorder: Do we need neuropsychologically impaired subtypes? Biol Psychiatry 2005; 57: 1224-1230.
  • Crosbie J, Pérusse D, Barr CL, Schachar RJ. Validating psychiatric endophenotypes: inhibitory control and attention deficit hyperactivity disorder. Neurosci Biobehav Rev 2008; 32: 40-55.
  • Rapport MD, Alderson RM, Kofler MJ, Sarver DE, Bolden J, Sims V. Working memory deficits in boys with attention-deficit/hyperactivity disorder (ADHD): The contribution of central executive and subsystem processes. J Abnorm Child Psychol 2008; 36: 825-837.
  • Sonuga-Barke EJS, Sergeant J a., Nigg J, Willcutt E. Executive Dysfunction and Delay Aversion in Attention Deficit Hyperactivity Disorder: Nosologic and Diagnostic Implications. Child Adolesc Psychiatr Clin N Am 2008; 17: 367-384.
  • Baddeley A. The fractionation of working memory. Proc Natl Acad Sci USA 1996; 93: 13468-13472.
  • Baddeley A. Working memory: theories, models, and controversies. Annu Rev Psychol 2012; 63: 1-29.
  • Cowan N. Visual and auditory working memory capacity. Trends Cogn Sci 1998; 2: 77.
  • Posner MI. Attention: the mechanisms of consciousness. Proc Natl Acad Sci USA 1994; 91: 7398-7403.
  • Comoldi C, Barbieri A, Gaiani C, Zocchi S. Strategic memory deficits in attention deficit disorder with hyperactivity participants: The role of executive processes. Dev Neuropsychol 1999; 15: 53-71.
  • Ott DA, Lyman RD. Automatic and Effortful Memory in Children Exhibiting Attention-Deficit Hyperactivity Disorder. J Clin Child Psychol 1993; 22: 420-427
  • Douglas VI, Benezra E. Supraspan verbal memory in attention deficit disorder with hyperactivity normal and reading-disabled boys. J Abnorm Child Psychol 1990; 18: 617-638.
  • Cahn DA, Marcotte AC. Rates of forgetting in attention deficit hyperactivity disorder. Child Neuropsychol 1995; 1: 158-163.
  • Denckla MB. ADHD: Topic update. Brain Dev 2003; 25: 383-389.
  • Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 1997; 121: 65-94.
  • Willcutt EG, Doyle AE, Nigg JT, Faraone S V, Pennington BF. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry 2005; 57: 1336-1346.
  • Chhabildas N, Pennington BF, Willcutt EG. A comparison of the neuropsychological profiles of the DSM-IV subtypes of ADHD. J Abnorm Child Psychol 2001; 29: 529-540.
  • Shanahan MA, Pennington BF, Yerys BE, et al. Processing speed deficits in attention deficit/ hyperactivity disorder and reading disability. J Abnorm Child Psychol 2006; 34: 585-602.
  • Rucklidge JJ, Tannock R. Neuropsychological profiles of adolescents with ADHD: effects of reading difficulties and gender. J Child Psychol Psychiatry 2002; 43: 988-1003.
  • Cole WR, Mostofsky SH, Larson JCG, Denckla MB, Mahone EM. Age-related changes in motor subtle signs among girls and boys with ADHD. Neurology 2008; 71: 1514-1520.
  • Mahone EM, Mostofsky SH, Lasker AG, Zee D, Denckla MB. Oculomotor Anomalies in Attention-Deficit/Hyperactivity Disorder: Evidence for Deficits in Response Preparation and Inhibition. J Am Acad Child Adolesc Psychiatry 2009; 48: 749-756.
  • Mostofsky SH, Simmonds DJ. Response inhibition and response selection: two sides of the same coin. J Cogn Neurosci 2008; 20: 751-761.
  • Sesma HW, Mahone EM, Levine T, Eason SH, Cutting LE. The contribution of executive skills to reading comprehension. Child Neuropsychol 2009; 15: 232-246.
  • Jacobson LA, Ryan M, Martin RB, et al. Working memory influences processing speed and reading fluency in ADHD. Child Neuropsychol 2011; 17: 209-224.
  • Eslinger PJ. Conceptualizing, describing, and measuring components of executive function: A summary. In: Attention, Memory, and Executive Function; 1996: 367-395.
  • Lezak MD, Howieson DB, Loring DW, Hannay HJ, Fischer JS. Neuropsychological Assessment (4th Ed.); 2004.
  • Tekin S, Cummings JL. Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J Psychosom Res 2002; 53: 647-654.
  • Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends Cogn Sci 2004; 8: 170-177.
  • Posner MI. Attentional networks and consciousness. Front Psychol 2012; 3: 64.
  • Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci 2001; 24: 167-202.
  • RUSHWORTH M, WALTON M, KENNERLEY S, BANNERMAN D. Action sets and decisions in the medial frontal cortex. Trends Cogn Sci 2004; 8: 410-417.
  • Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 2002; 3: 201-215.
  • Botvinick M, Braver T. Motivation and Cognitive Control: From Behavior to Neural Mechanism. Annu Rev Psychol 2014; 66: 83-113.
  • Paxton JL, Barch DM, Racine CA, Braver TS. Cognitive control, goal maintenance, and prefrontal function in healthy aging. Cereb Cortex 2008; 18: 1010-1028.
  • Fair DA, Nigg JT, Iyer S, et al. Distinct neural signatures detected for ADHD subtypes after controlling for micro-movements in resting state functional connectivity MRI data. Front Syst Neurosci 2013; 6: 80.
  • Nelson SM, Dosenbach NUF, Cohen AL, Wheeler ME, Schlaggar BL, Petersen SE. Role of the anterior insula in task-level control and focal attention. Brain Struct Funct 2010; 214: 669-680.
  • Bunge SA, Wright SB. Neurodevelopmental changes in working memory and cognitive control. Curr Opin Neurobiol 2007; 17: 243-250.
  • Daigneault S, Braün CM, Whitaker HA. An empirical test of two opposing theoretical models of prefrontal function. Brain Cogn 1992; 19: 48-71.
  • Scheres A, Oosterlaan J, Geurts H, et al. Executive functioning in boys with ADHD: Primarily an inhibition deficit? Arch Clin Neuropsychol 2004; 19: 569-594.
  • Geurts HM, Verté S, Oosterlaan J, Roeyers H, Sergeant J a. ADHD subtypes: Do they differ in their executive functioning profile? Arch Clin Neuropsychol 2005; 20: 457-477.
  • Stuss DT. Biological and psychological development of executive functions. Brain Cogn 1992; 20: 8-23.
  • Klenberg L, Korkman M, Lahti-Nuuttila P. Differential development of attention and executive functions in 3- to 12-year-old Finnish children. Dev Neuropsychol 2001; 20: 407-428.
  • Vaidya CJ, Stollstorff M. Cognitive neuroscience of Attention Deficit Hyperactivity Disorder: current status and working hypotheses. Dev Disabil Res Rev 2008; 14: 261-267.
  • Nigg JT. Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: The state of the field and salient challenges for the coming decade. Biol Psychiatry 2005; 57: 1424-1435.
  • Castellanos FX, Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 2002; 3: 617-628.
  • Durston S, Mulder M, Casey BJ, Ziermans T, van Engeland H. Activation in Ventral Prefrontal Cortex is Sensitive to Genetic Vulnerability for Attention-Deficit Hyperactivity Disorder. Biol Psychiatry 2006; 60: 1062-1070.
  • Casey BJ, Durston S. From behavior to cognition to the brain and back: what have we learned from functional imaging studies of attention deficit hyperactivity disorder? Am J Psychiatry 2006; 163: 957-960.
  • Mennes M, Vega Potler N, Kelly C, Di Martino A, Castellanos FX, Milham MP. Resting State Functional Connectivity Correlates of Inhibitory Control in Children with Attention-Deficit/ Hyperactivity Disorder. Front Psychiatry 2012; 2: 83.
  • Aron AR. From reactive to proactive and selective control: developing a richer model for stopping inappropriate responses. Biol Psychiatry 2011; 69: e55-e68.
  • Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex: one decade on. Trends Cogn Sci 2014; 18: 177-185.
  • Seidman LJ. Neuropsychological functioning in people with ADHD across the lifespan. Clin Psychol Rev 2006; 26: 466-485.
  • Pasini A, Paloscia C, Alessandrelli R, Porfirio MC, Curatolo P. Attention and executive functions profile in drug naive ADHD subtypes. Brain Dev 2007; 29: 400-408.
  • Goldman-Rakic PS. Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates. Prog Brain Res 1990; 85: 325-335.
  • Fuster JM. Network memory. Trends Neurosci 1997; 20: 451-459.
  • Goldman-Rakic PS. Cellular basis of working memory. Neuron 1995; 14: 477-485.
  • Barkley R a, Edwards G, Laneri M, Fletcher K, Metevia L. Executive functioning, temporal discounting, and sense of time in adolescents with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). J Abnorm Child Psychol 2001; 29: 541-556.
  • Kessler RC, Adler L a., Barkley R, et al. Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: Results from the national comorbidity survey replication. Biol Psychiatry 2005; 57: 1442-1451.
  • Frazier TW, Demaree H a, Youngstrom E a. Metaanalysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder. Neuropsychology 2004; 18: 543-555.
  • Alderson RM, Kasper LJ, Hudec KL, Patros CHG. Attention-deficit/hyperactivity disorder (ADHD) and working memory in adults: a meta-analytic review. Neuropsychology 2013; 27: 287-302.
  • Seidman LJ, Biederman J, Faraone S V, et al. Effects of family history and comorbidity on the neuropsychological performance of children with ADHD: preliminary findings. J Am Acad Child Adolesc Psychiatry 1995; 34: 1015-1024.
  • van Ewijk H, Heslenfeld DJ, Luman M, et al. Visuospatial working memory in ADHD patients, unaffected siblings, and healthy controls. J Atten Disord 2014; 18: 369-378.
  • Dovis S, Van der Oord S, Wiers RW, Prins PJM. ADHD Subtype Differences in Reinforcement Sensitivity and Visuospatial Working Memory. J Clin Child Adolesc Psychol 2015; 44: 859-874.
  • Zakay D. The role of attention in children’s time perception. J Exp Child Psychol 1992; 54: 355-371.
  • Mimura M, Kinsbourne M, O’Connor M. Time estimation by patients with frontal lesions and by Korsakoff amnesics. J Int Neuropsychol Soc 2000; 6: 517-528.
  • Martinussen R, Hayden J, Hogg-Johnson S, Tannock R. A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2005; 44: 377-384.
  • Kasper LJ, Alderson RM, Hudec KL. Moderators of working memory deficits in children with attention-deficit/hyperactivity disorder (ADHD): a meta-analytic review. Clin Psychol Rev 2012; 32: 605-617.
  • Weyandt LL. Executive function in children, adolescents, and adults with attention deficit hyperactivity disorder: introduction to the special issue. Dev Neuropsychol 2005; 27: 1-10.
  • Aman CJ, Roberts RJ, Pennington BF. A neuropsychological examination of the underlying deficit in attention deficit hyperactivity disorder: frontal lobe versus right parietal lobe theories. Dev Psychol 1998; 34: 956-969.
  • Carter CS, Krener P, Chaderjian M, Northcutt C, Wolfe V. Abnormal processing of irrelevant information in attention deficit hyperactivity disorder. Psychiatry Res 1995; 56: 59-70.
  • Pineda D, Ardila A, Rosselli M. Neuropsychological and behavioral assessment of ADHD in seven- to twelve-year-old children: a discriminant analysis. J Learn Disabil 1999; 32: 159-173.
  • Baker SC, Rogers RD, Owen AM, et al. Neural systems engaged by planning: a PET study of the Tower of London task. Neuropsychologia 1996; 34: 515-526.
  • Capilla Gonzalez A, Etchepareborda MC, Fernandez Gonzalez S, et al. [The neurofunctional foundation of cognitive rigidity in attention deficit hyperactivity disorder: some preliminary findings]. Rev Neurol 2004; 38 Suppl 1: S145-S148.
  • Sergeant JA, Geurts H, Oosterlaan J. How specific is a deficit of executive functioning for attentiondeficit/ hyperactivity disorder? Behav Brain Res 2002; 130: 3-28.
  • Rhodes SM, Coghill DR, Matthews K. Neuropsychological functioning in stimulantnaive boys with hyperkinetic disorder. Psychol Med 2005; 35: 1109-1120.
  • Nigg JT, Casey BJ. An integrative theory of attention-deficit/ hyperactivity disorder based on the cognitive and affective neurosciences. Dev Psychopathol 2005; 17: 785-806.
  • Pasini A, Paloscia C, Alessandrelli R, Porfirio MC, Curatolo P. Attention and executive functions profile in drug naive ADHD subtypes. Brain Dev 2007; 29: 400-408.
  • Barkley RA. Advances in the diagnosis and subtyping of attention deficit hyperactivity disorder: what may lie ahead for DSM-V. Rev Neurol 2009; 48 Suppl 2: S101-S106.
  • Antrop I, Stock P, Verté S, Wiersema JR, Baeyens D, Roeyers H. ADHD and delay aversion: the influence of non-temporal stimulation on choice for delayed rewards. J Child Psychol Psychiatry 2006; 47: 1152-1158.
  • Solanto M V, Abikoff H, Sonuga-Barke E, et al. The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: a supplement to the NIMH multimodal treatment study of AD/HD. J Abnorm Child Psychol 2001; 29: 215-228.
  • Sonuga-Barke EJS. Psychological heterogeneity in AD/HD--a dual pathway model of behaviour and cognition. Behav Brain Res 2002; 130: 29-36.
  • Biederman J, Monuteaux MC, Doyle AE, et al. Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in children. J Consult Clin Psychol 2004; 72: 757-766.
  • Luman M, Oosterlaan J, Sergeant J. The impact of reinforcement contingencies on AD/HD: A review and theoretical appraisal. Clin Psychol Rev 2005; 25: 183-213.
  • Rogers RD, Ramnani N, Mackay C, et al. Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition. Biol Psychiatry 2004; 55: 594-602.
  • Cardinal RN. Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core. Science 2001; 292: 2499-2501.
  • Doyle A. Executive functions in attention-deficit/hyperactivity disorder. J Clin Psychiatry 2005; 67 (suppl 8): 21-26.
Fuente de los datos: Dialnet