Retinopatía MEKCasos clínicos

  1. P.Rocha Cabrera 1
  2. E.Quijada Fumero 1
  3. M.J.Losada Castillo 1
  4. J.A.Abreu Reyes 1
  5. J.Lorenzo Morales 1
  1. 1 Servicio de Oftalmología, Hospital Universitario de Canarias, La Laguna (Tenerife), España
Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2018

Volume: 93

Issue: 1

Pages: 42-46

Type: Article

DOI: 10.1016/J.OFTAL.2017.03.005 DIALNET GOOGLE SCHOLAR

More publications in: Archivos de la Sociedad Española de Oftalmologia

Abstract

Case reports: Three clinical cases are presented of MEK retinopathy associated with the combination of cobimetinib and vemurafenib characterised by alteration of the retinal pigment epithelium and neurosensory detachment. Two of the cases conserved the vision of the unit, and the third developed a large bilateral neurosensory detachment with final visual acuity of 0.6 for the right eye and 0.1 for the left one. Discussion: The new therapeutic strategies against metastatic cutaneous melanoma condition the appearance of alterations of the pigmentary epithelium of the retina with serous detachments, leading to close monitoring with macular optical coherence tomography.

Data source: Dialnet