Estudio funcional y molecular del canal Maxi-Cl activado por antiestrógenos

  1. Bahamonde Santos, María Isabel
Supervised by:
  1. Miquel Angel Valverde Castro Director

Defence university: Universitat Pompeu Fabra

Fecha de defensa: 28 April 2004

Committee:
  1. Fernando Giraldes Orgaz Chair
  2. Gabriel Gil Gómez Secretary
  3. Mario Lorenzo Díaz González Committee member
  4. Luis Miguel García Segura Committee member
  5. Ángel Nadal Navajas Committee member

Type: Thesis

Teseo: 106657 DIALNET lock_openTDX editor

Abstract

Cellular membranes contain a Maxi-Cl- channel that is modulated by oestrogen and antioestrogens. The experimental work of my PhD Thesis has focussed in the study of the molecular identity of the Maxi-Cl- channel and its regulation. My results demonstrated that an isoform of the mitochondrial protein VDAC is the molecular correlate of the Maxi-Cl- channel and that the activation of the channel by antioestrogens and its inhibition by oestrogen requires a dephosphorylation and phosphorylation process, respectively.