Estudio funcional y molecular del canal Maxi-Cl activado por antiestrógenos
- Bahamonde Santos, María Isabel
- Miquel Angel Valverde Castro Director
Universidade de defensa: Universitat Pompeu Fabra
Fecha de defensa: 28 de abril de 2004
- Fernando Giraldes Orgaz Presidente/a
- Gabriel Gil Gómez Secretario/a
- Mario Lorenzo Díaz González Vogal
- Luis Miguel García Segura Vogal
- Ángel Nadal Navajas Vogal
Tipo: Tese
Resumo
Cellular membranes contain a Maxi-Cl- channel that is modulated by oestrogen and antioestrogens. The experimental work of my PhD Thesis has focussed in the study of the molecular identity of the Maxi-Cl- channel and its regulation. My results demonstrated that an isoform of the mitochondrial protein VDAC is the molecular correlate of the Maxi-Cl- channel and that the activation of the channel by antioestrogens and its inhibition by oestrogen requires a dephosphorylation and phosphorylation process, respectively.