Estudio funcional y molecular del canal Maxi-Cl activado por antiestrógenos

  1. Bahamonde Santos, María Isabel
Dirigée par:
  1. Miquel Angel Valverde Castro Directeur/trice

Université de défendre: Universitat Pompeu Fabra

Fecha de defensa: 28 avril 2004

Jury:
  1. Fernando Giraldes Orgaz President
  2. Gabriel Gil Gómez Secrétaire
  3. Mario Lorenzo Díaz González Rapporteur
  4. Luis Miguel García Segura Rapporteur
  5. Ángel Nadal Navajas Rapporteur

Type: Thèses

Teseo: 106657 DIALNET lock_openTDX editor

Résumé

Cellular membranes contain a Maxi-Cl- channel that is modulated by oestrogen and antioestrogens. The experimental work of my PhD Thesis has focussed in the study of the molecular identity of the Maxi-Cl- channel and its regulation. My results demonstrated that an isoform of the mitochondrial protein VDAC is the molecular correlate of the Maxi-Cl- channel and that the activation of the channel by antioestrogens and its inhibition by oestrogen requires a dephosphorylation and phosphorylation process, respectively.