Estudio funcional y molecular del canal Maxi-Cl activado por antiestrógenos
- Bahamonde Santos, María Isabel
- Miquel Angel Valverde Castro Zuzendaria
Defentsa unibertsitatea: Universitat Pompeu Fabra
Fecha de defensa: 2004(e)ko apirila-(a)k 28
- Fernando Giraldes Orgaz Presidentea
- Gabriel Gil Gómez Idazkaria
- Mario Lorenzo Díaz González Kidea
- Luis Miguel García Segura Kidea
- Ángel Nadal Navajas Kidea
Mota: Tesia
Laburpena
Cellular membranes contain a Maxi-Cl- channel that is modulated by oestrogen and antioestrogens. The experimental work of my PhD Thesis has focussed in the study of the molecular identity of the Maxi-Cl- channel and its regulation. My results demonstrated that an isoform of the mitochondrial protein VDAC is the molecular correlate of the Maxi-Cl- channel and that the activation of the channel by antioestrogens and its inhibition by oestrogen requires a dephosphorylation and phosphorylation process, respectively.